Post-operative Radiotherapy Omission in Selected Patients With Early Breast Cancer Trial International VErsion (PROSPECTIVE)

This international trial (PROSPECTIVE) is studying whether selected women with early-stage breast cancer can safely skip radiation therapy after breast-conserving surgery (lumpectomy). It focuses on women with low-risk tumors to see if omitting radiation does not worsen their long-term outcomes. **You may be eligible if...** - You are a woman aged 50 or older with confirmed estrogen receptor-positive and/or HER2-positive breast cancer - Your cancer is in one location in one breast (unifocal, unilateral) - You have a life expectancy of at least 10 years and are willing to be followed for 10 years - You are in reasonably good health (ECOG 0–2) **You may NOT be eligible if...** - Your cancer is triple-negative (ER-negative, PR-negative, HER2-negative) - You have had a previous breast cancer or chest radiation - Your cancer has spread to distant organs - You carry a known breast cancer gene mutation (such as BRCA1 or BRCA2) - You are planning a mastectomy - You have bilateral breast cancer Talk to your doctor to see if this trial is right for you.