RecruitingPhase 2NCT06448754

Volrustomig Priming Regimens Exploratory Phase II Platform Study

A Phase II, Open-label Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Immunogenicity, and Antitumor Activity of Volrustomig Priming Regimens in Combination With Other Anticancer Agents in Participants With Solid Tumors (eVOLVE-01)

Sponsor

AstraZeneca

Enrollment

180 participants

Start Date

Aug 27, 2024

Study Type

INTERVENTIONAL

Conditions

Non-small Cell Lung Cancer

Summary

Purpose of this study is to assess the safety, tolerability, pharmacokinetics, immunogenicity, and antitumor activity of volrustomig in combination with other anticancer drugs in participants with specified solid tumors.

Eligibility

Min Age: 18 YearsMax Age: 130 Years

Plain Language Summary

Simplified for easier understanding

This Phase II study explores different "priming" regimens to give alongside volrustomig, a dual immune checkpoint inhibitor, in advanced non-small cell lung cancer. The goal is to find which combination approach best activates the immune system against the tumor. **You may be eligible if...** - You have histologically confirmed advanced non-small cell lung cancer (NSCLC) - Your tumor does not have sensitizing EGFR mutations - You have good overall function (ECOG 0 or 1) and adequate organ function - Your body weight is above 35 kg - Your life expectancy is at least 12 weeks **You may NOT be eligible if...** - You have EGFR mutations in your tumor - Your overall health is too poor to tolerate treatment Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGVolrustomig

Participants will receive volrustomig via intravenous (IV) infusion.

DRUGCarboplatin

Participants will receive carboplatin via IV infusion.

DRUGPemetrexed

Participants will receive pemetrexed via IV infusion.

DRUGRamucirumab

Participants will receive ramucirumab via IV infusion.

DRUGPaclitaxel

Participants will receive paclitaxel via IV infusion.

Locations(77)

Research Site

Los Angeles, California, United States

Research Site

Grand Junction, Colorado, United States

Research Site

Wheat Ridge, Colorado, United States

Research Site

Baltimore, Maryland, United States

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Detroit, Michigan, United States

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Chapel Hill, North Carolina, United States

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Tacoma, Washington, United States

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Montreal, Quebec, Canada

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Beijing, China

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Hangzhou, China

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Jinan, China

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Yantai, China

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Zhengzhou, China

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Bois-Guillaume, France

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Caen, France

Research Site

Créteil, France

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Dijon, France

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Montpellier, France

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Batumi, Georgia

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Tbilisi, Georgia

Research Site

Tbilisi, Georgia

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Tbilisi, Georgia

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Tbilisi, Georgia

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Tbilisi, Georgia

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Athens, Greece

Research Site

Athens, Greece

Research Site

Elaiones, Greece

Research Site

Piraeus, Greece

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Thessaloniki, Greece

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Genoa, Italy

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Meldola, Italy

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Milan, Italy

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Naples, Italy

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Orbassano, Italy

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Perugia, Italy

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Rozzano, Italy

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Udine, Italy

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Verona, Italy

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Kuala Lumpur, Malaysia

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Kuching, Malaysia

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Perai, Malaysia

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Lisbon, Portugal

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Lisbon, Portugal

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Lisbon, Portugal

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Lisbon, Portugal

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Porto, Portugal

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Porto, Portugal

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Cluj-Napoca, Romania

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Craiova, Romania

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Floreşti, Romania

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Belgrade, Serbia

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Belgrade, Serbia

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Kamenitz, Serbia

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Kragujevac, Serbia

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Seongnam, South Korea

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Seoul, South Korea

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Seoul, South Korea

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Suwon, South Korea

Research Site

A Coruña, Spain

Research Site

Alcorcón, Spain

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Barcelona, Spain

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Madrid, Spain

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Málaga, Spain

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Pamplona, Spain

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Santander, Spain

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Santiago de Compostela, Spain

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Valencia, Spain

Research Site

Valencia, Spain

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Basel, Switzerland

Research Site

Geneva, Switzerland

Research Site

Lausanne, Switzerland

Research Site

Winterthur, Switzerland

Research Site

Zurich, Switzerland

Research Site

Changhua, Taiwan

Research Site

New Taipei City, Taiwan

Research Site

Taipei, Taiwan

Research Site

Taipei, Taiwan

View Full Details on ClinicalTrials.gov

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NCT06448754

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