RecruitingNot ApplicableNCT06449326

Multimodal Image Analysis and Guidance of Neuromodulation for Trauma-Related Symptoms


Sponsor

University of New Mexico

Enrollment

64 participants

Start Date

Jun 1, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

MAGNETS is a prospective, randomized, parallel-design, sham-controlled clinical trial of accelerated, functional magnetic resonance imaging (fMRI)-guided intermittent theta burst stimulation (iTBS) to the right dorsolateral prefrontal cortex (dlPFC) for chronic symptoms of posttraumatic stress disorder (PTSD) in a comorbid Veteran population.


Eligibility

Min Age: 18 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study uses brain imaging and non-invasive brain stimulation (neuromodulation) to better understand and potentially treat PTSD symptoms in military veterans. Researchers will use MRI and other tools to map how trauma affects brain circuits. **You may be eligible if...** - You are a veteran aged 18–80 - You have a documented diagnosis of PTSD and are currently experiencing significant symptoms (scoring 31 or higher on the PCL-5 scale) - You are fluent in English - You have been on stable psychiatric medications for the past month **You may NOT be eligible if...** - You have a history of other neurological conditions - You are not a veteran - Your PTSD medications are not stable Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEActive Intermittent theta burst stimulation

Intermittent theta burst stimulation (iTBS) is an efficient form of transcranial magnetic stimulation that allows up to 10x more pulses to be delivered in a given timeframe compared to conventional stimulation patterns.

DEVICESham Intermittent theta burst stimulation

Intermittent theta burst stimulation (iTBS) is an efficient form of transcranial magnetic stimulation that allows up to 10x more pulses to be delivered in a given timeframe compared to conventional stimulation patterns.


Locations(2)

UNM Center for Psychiatric Research

Albuquerque, New Mexico, United States

New Mexico VA Health Care System

Albuquerque, New Mexico, United States

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NCT06449326


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