Posttraumatic Stress Disorder Clinical Trials

52 recruiting

Frequently Asked Questions

Common questions about Posttraumatic Stress Disorder clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 70 trials

Recruiting
Phase 2

Ketamine, SGB and Combination Treatment for TBI

Posttraumatic Stress DisorderPosttraumatic Headache
Northwestern University175 enrolled3 locationsNCT06608277
Recruiting

LHC-CIDI-5 in Hong Kong

Suicidal IdeationObsessive Compulsive Disorder (OCD)Major Depressive Disorder (MDD)+20 more
The University of Hong Kong2,500 enrolled1 locationNCT06804525
Recruiting
Not Applicable

Transdiagnostic Metacognitive Therapy Compared to Disorder-Specific Cognitive-Behavioral Therapy for Anxiety Disorders

Posttraumatic Stress Disorder (PTSD)Generalized Anxiety Disorder (GAD)Social Anxiety Disorder (SAD)
Karolinska Institutet86 enrolled1 locationNCT06937892
Recruiting
Not Applicable

CIH Stepped Care for Co-occurring Chronic Pain and PTSD

Chronic PainPosttraumatic Stress Disorder
University of Washington60 enrolled1 locationNCT06219408
Recruiting
Not Applicable

Augmenting Massed Cognitive Processing Therapy (CPT) to Prevent Suicide Risk Among Patients With PTSD

Suicidal IdeationPosttraumatic Stress Disorder (PTSD)Suicide Attempt
Ohio State University190 enrolled1 locationNCT07238192
Recruiting
Not Applicable

Written Exposure Therapy for Veterans With SUD and PTSD

Substance Use DisordersPosttraumatic Stress Disorder
VA Office of Research and Development170 enrolled1 locationNCT05327504
Recruiting
Not Applicable

Efficacy of an EMDR App for PTSD and SUD

Substance Use DisordersPosttraumatic Stress Disorder (PTSD)
Centre for Addiction and Mental Health24 enrolled1 locationNCT07146633
Recruiting
Not Applicable

Trauma BPE Prolonged Exposure Therapy for Injured Individuals Admitted to a Level I Trauma Center

PTSDPosttraumatic Stress DisorderTraumatic Injury
Baylor Research Institute300 enrolled3 locationsNCT06210711
Recruiting
Not Applicable

Advancing Couple and Family Alcohol Treatment Through Patient-Oriented Research and Mentorship

Alcohol Use DisorderPosttraumatic Stress DisorderCouples
Medical University of South Carolina140 enrolled1 locationNCT05786157
Recruiting
Not Applicable

Enhancing Psychotherapy for Veterans and Service Members With PTSD and Anxiety

Anxiety DisordersPosttraumatic Stress Disorder
Baylor College of Medicine306 enrolled1 locationNCT05843695
Recruiting
Phase 1Phase 2

Mitigating PTSD-CUD After Sexual Assault

Cannabis Use DisorderPosttraumatic Stress Disorder
University of Nevada, Las Vegas68 enrolled6 locationsNCT05989841
Recruiting
Not Applicable

Evaluation of the PE Coach Mobile Application Among Veterans With PTSD

Posttraumatic Stress Disorder
VA Office of Research and Development124 enrolled1 locationNCT04959695
Recruiting
Phase 4

Methylphenidate for the Treatment of PTSD With Associated Neurocognitive Complaints

Posttraumatic Stress Disorder (PTSD)
VA Office of Research and Development70 enrolled3 locationsNCT05776056
Recruiting
Not Applicable

Art Therapy and Emotional Well Being in Military Populations With Posttraumatic Stress Symptoms

Sleep DisturbancePTSDEmotional Regulation+12 more
Walter Reed National Military Medical Center40 enrolled2 locationsNCT05414708
Recruiting
Phase 2

Ayahuasca, Esketamine and PTSD

Posttraumatic Stress Disorder (PTSD)
University of Sao Paulo10 enrolled1 locationNCT07317206
Recruiting
Not Applicable

Adaptive Decision-making And Personalized Treatment for PTSD (ADAPT-PTSD)

PTSDPosttraumatic Stress Disorder
The University of Texas Health Science Center at San Antonio302 enrolled4 locationsNCT07176273
Recruiting
Phase 1

Inflammatory Challenge and Fear

Posttraumatic Stress Disorder (PTSD)
University of California, San Francisco288 enrolled1 locationNCT06630884
Recruiting
Not Applicable

Open Pilot Trial of Adapted Cognitive Processing Therapy for Comorbid PTSD and Opioid Use Disorder

Opioid-use DisorderPosttraumatic Stress Disorder (PTSD)
The City College of New York15 enrolled1 locationNCT06872164
Recruiting
Not Applicable

Integrated Treatment for Opioid Use Disorder and PTSD

Opioid-use DisorderPosttraumatic Stress Disorder (PTSD)
Medical University of South Carolina76 enrolled1 locationNCT06641115
Recruiting
Not Applicable

A Mechanistic Trial of the Neurobiology of Extinction Learning and Intraparietal Sulcus Stimulation

Posttraumatic Stress Disorder
University of Pennsylvania120 enrolled1 locationNCT06234969