Posttraumatic Stress Disorder Clinical Trials

94 recruitingLast updated: June 18, 2026

There are 94 actively recruiting posttraumatic stress disorder clinical trials across 16 countries. Studies span Not Applicable, Phase 2, Phase 1, Early Phase 1, Phase 3, Phase 4. Top locations include Boston, Massachusetts, United States, Seattle, Washington, United States, Houston, Texas, United States. Updated daily from ClinicalTrials.gov.


Posttraumatic Stress Disorder Trials at a Glance

94 actively recruiting trials for posttraumatic stress disorder are listed on ClinicalTrialsFinder across 6 cities in 16 countries. The largest study group is Not Applicable with 61 trials, with the heaviest enrollment activity in Boston, Seattle, and Houston. Lead sponsors running posttraumatic stress disorder studies include VA Office of Research and Development, Medical University of South Carolina, and Karolinska Institutet.

Browse posttraumatic stress disorder trials by phase

Treatments under study

About Posttraumatic Stress Disorder Clinical Trials

Looking for clinical trials for Posttraumatic Stress Disorder? There are currently 82 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Posttraumatic Stress Disorder trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Posttraumatic Stress Disorder clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 94 trials

Recruiting
Not Applicable

Reducing Psychological Barriers to PrEP Persistence Among Pregnant and Postpartum Women in Cape Town, South Africa

DepressionPregnancy RelatedMedication Adherence+1 more
Boston University Charles River Campus118 enrolled2 locationsNCT05624931
Recruiting
Not Applicable

Cognitive Processing Therapy (CPT) for Perinatal Posttraumatic Stress Disorder (PTSD)

PregnancyPosttraumatic Stress Disorder (PTSD)
University of Texas at Austin60 enrolled1 locationNCT07060144
Recruiting
Not Applicable

Integrated Health Care for PTSD

Posttraumatic Stress Disorder (PTSD)
Veterans Medical Research Foundation300 enrolled5 locationsNCT07220681
Recruiting
Not Applicable

Self-Help Cognitive Processing Therapy (CPT)/Women Veterans Network (WoVeN) Study

DepressionPosttraumatic Stress Disorder
Boston University100 enrolled1 locationNCT07250061
Recruiting
Not Applicable

Efficacy of an EMDR App for PTSD and SUD

Substance Use DisordersPosttraumatic Stress Disorder (PTSD)
Centre for Addiction and Mental Health24 enrolled1 locationNCT07146633
Recruiting

Validation of the CIDI 5.0 Against the SCID-5 for Lifetime Mental Disorders

Major Depressive Disorder (MDD)Posttraumatic Stress Disorder (PTSD)Generalized Anxiety Disorder (GAD)
The University of Hong Kong300 enrolled1 locationNCT07604753
Recruiting
Not Applicable

Novel Telemedicine-Delivered Prolonged Exposure Therapy for Treating PTSD in Individuals With OUD

Opioid-use DisorderPosttraumatic Stress Disorder
University of Vermont135 enrolled1 locationNCT06288711
Recruiting
Not Applicable

Prolonged Exposure Therapy to Treat Posttraumatic Stress Disorder in Pregnant Patients

PregnancyPosttraumatic Stress Disorder
University of Vermont30 enrolled1 locationNCT06670079
Recruiting
Not Applicable

A Precision Medicine Approach to Target Engagement for Emotion Regulation

DepressionAnxietyEating Disorders+4 more
Matthew Southward, PhD390 enrolled1 locationNCT05651295
Recruiting
Not Applicable

EMDR Treatment in PTSD Following Cardiac Events

Eye Movement Desensitization and ReprocessingMyocardial InfarctionPosttraumatic Stress Disorder
University of Zurich60 enrolled1 locationNCT04672551
Recruiting
Phase 2

Ketamine, SGB and Combination Treatment for TBI-associated Headache or PTSD

Posttraumatic Stress DisorderPosttraumatic Headache
Northwestern University175 enrolled3 locationsNCT06608277
Recruiting
Not Applicable

Two-week Intensive Outpatient Trauma Treatment.

Posttraumatic Stress Disorder (PTSD)
Oslo University Hospital42 enrolled1 locationNCT07565311
Recruiting
Phase 2

Integration of Cognitive Processing Therapy and Relapse Prevention for Alcohol Use Disorder and PTSD

Alcohol Use DisorderPosttraumatic Stress Disorder
Texas A&M University200 enrolled2 locationsNCT05959434
Recruiting
Not Applicable

Improving Cognitive Rehabilitation Outcomes

Mild Traumatic Brain InjuryPosttraumatic Stress Disorder
VA Office of Research and Development144 enrolled2 locationsNCT07055633
Recruiting
Not Applicable

Multicenter iTBS Neuromodulation for PTSD Treatment

Posttraumatic Stress Disorder
Second Affiliated Hospital, School of Medicine, Zhejiang University140 enrolled5 locationsNCT06434766
Recruiting
Not Applicable

Brief Behavioral Treatment for Insomnia in Veterans With Posttraumatic Stress Disorder

Insomnia DisorderPosttraumatic Stress Disorder
VA Office of Research and Development200 enrolled1 locationNCT05780177
Recruiting
Not Applicable

Insomnia Treatment and Cardiometabolic Health in Older Adults With Posttraumatic Stress Disorder

InsomniaCardiovascular DiseasesMetabolic Disease+1 more
University of California, Los Angeles167 enrolled1 locationNCT05516277
Recruiting
Not Applicable

Advancing Couple and Family Alcohol Treatment Through Patient-Oriented Research and Mentorship

Alcohol Use DisorderPosttraumatic Stress DisorderCouples
Medical University of South Carolina140 enrolled1 locationNCT05786157
Recruiting
Not Applicable

Mindfulness-based Stress Reduction for PTSD in Road Traffic Accident Victims: A Randomized Controlled Trial

Posttraumatic Stress Disorder (PTSD)
Universiti Sains Malaysia110 enrolled1 locationNCT07521020
Recruiting
Phase 3

Repurposing Low-Dose Clonidine for PTSD in Veterans

SleepPTSDPosttraumatic Stress Disorder
Wake Forest University Health Sciences32 enrolled1 locationNCT04877093