KHENERFIN Study: A Trial to Evaluate the Efficacy and Safety of Sonlicromanol in Primary Mitochondrial Diseases

This study tests a drug called sonlicromanol in people with a specific inherited mitochondrial disease (a genetic condition where the body's energy-producing cells don't work properly). The trial focuses on patients with the m.3243A>G mutation who experience fatigue and muscle weakness. **You may be eligible if...** - You are 18 or older with a confirmed m.3243A>G mitochondrial DNA mutation - You have been experiencing chronic fatigue for at least 3 months - You have measurable muscle weakness (assessed by a sit-to-stand test) - Your mutation level in the blood or other tissue is 20% or higher **You may NOT be eligible if...** - You have taken an investigational drug within the past 3 months - You have severe organ problems that could interfere with the study - You are pregnant or planning to become pregnant Talk to your doctor to see if this trial is right for you.