Postoperative Re-irradiaTion With and Without HYPERthermia: Toxicity, Quality of Life and Survival in Patients With Locoregional Recurrent Breast Cancer

This study examines whether adding hyperthermia (heat therapy) to re-irradiation (a second course of radiation) improves outcomes for breast cancer patients whose cancer has come back in the chest wall or nearby lymph nodes after they previously received radiation treatment. **You may be eligible if...** - You are 18 or older with breast cancer that has returned locally (in the chest wall, skin, or nearby lymph nodes) after previous radiation treatment - You have had salvage surgery (mastectomy or local excision) with high-risk features, or need postoperative re-irradiation - You are in reasonably good health (WHO performance score 2 or below) - You can understand Dutch-language instructions **You may NOT be eligible if...** - You have primary breast sarcoma - Your recurrence is considered low-risk after previous breast-conserving surgery - You have more than 5 spread lesions in distant lymph nodes Talk to your doctor to see if this trial is right for you.