Amygdala and dLPFC MRI-TIS for Depression in Adolescents

This study tests a non-invasive brain stimulation technique called Temporal Interference Stimulation (TIS) — which uses mild electrical currents to activate deep brain regions — to treat depression in teenagers aged 14–18. The study targets two brain areas (the amygdala and prefrontal cortex) that are linked to mood regulation. **You may be eligible if...** - You are aged 14–18 and have been diagnosed with depression by a study doctor - Your depression is moderate to severe (HAMD-17 score of 17 or higher) - Your antidepressant medication, if any, has been stable for at least 30 days **You may NOT be eligible if...** - You have a history of epilepsy or seizures - You have metal implants in your head or a metal heart device - You have another diagnosed neurological or psychiatric condition that could affect the results - You have an organic brain disease (such as a brain tumor or stroke) Talk to your doctor to see if this trial is right for you.