RecruitingNot ApplicableNCT06457230

Cerebellum-Prefrontal Paired-Pulse Stimulation for Methamphetamine Use Disorder

Exploring the Mechanisms and Efficacy of Cerebellum-Medial Prefrontal Cortex-Based Paired-Pulse Repetitive Transcranial Magnetic Stimulation for Methamphetamine Use Disorder

Sponsor

Shanghai Mental Health Center

Enrollment

90 participants

Start Date

Dec 24, 2024

Study Type

INTERVENTIONAL

Conditions

Methamphetamine Use Disorder

Summary

To investigate the mechanism and efficacy of a novel repetitive transcranial magnetic stimulation (rTMS) intervention model with paired cerebellar-medial prefrontal cortex (mPFC) pulses on methamphetamine use disorder patients and to develop a novel physiotherapeutic intervention to optimise the treatment and management.

Eligibility

Sex: MALEMin Age: 18 YearsMax Age: 60 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a medical device called Paired Associative Stimulation Targeting the Cerebellar-mPFC, a medical device called Sham Intervention over cerebellum and mPFC, and others for people with methamphetamine use disorder. The study is currently recruiting participants at 1 location. People eligible for this study include men aged 18 Years to 60 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DEVICEPaired Associative Stimulation Targeting the Cerebellar-mPFC

The protocol consisted of 180 pulse trains. Each train contained 5 pulse pairs delivered over 1 second, resulting in a stimulation frequency of 5 Hz. Within each pulse pair, the cerebellum was stimulated first, followed by the mPFC after a 6-ms inter-stimulus interval (ISI). In total, 900 pulse pairs were administered, and a complete intervention session lasted 11 minutes and 57 seconds.

DEVICESham Intervention over cerebellum and mPFC

The coil will be placed vertically over the cerebellar and mPFC brain regions, allowing participants to perceive the coil's vibration and sound without receiving effective intervention. All other stimulation parameters are identical to those in the active intervention group.

DEVICESham stimulation over the cerebellum + real stimulation over the medial prefrontal cortex

Participants in this group will receive sham stimulation over the cerebellum (The coil will be placed vertically over the cerebellum) combined with real stimulation over the medial prefrontal cortex.