RecruitingPhase 1NCT06462183

Study of Safety and Efficacy of RGT-61159 in Adults With Relapsed/Refractory Adenoid Cystic Carcinoma (ACC) or Colorectal Carcinoma (CRC)

A Phase 1a/1b, First-in-human, Multicenter Study to Assess the Efficacy and Safety of RGT-61159 for Treatment of Patients With Relapsed/Refractory Adenoid Cystic Carcinoma (ACC) or Colorectal Carcinoma (CRC)


Sponsor

Rgenta Therapeutics Inc

Enrollment

105 participants

Start Date

Aug 19, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

Phase 1 study to evaluate safety, tolerability and anti-tumor activity of RGT-61159 in patients with ACC or CRC


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This trial tests a new drug called RGT-61159 in adults with two specific types of cancer that have come back or stopped responding to treatment: adenoid cystic carcinoma (a rare cancer often found in salivary glands) and colorectal cancer (bowel cancer). **You may be eligible if...** - You have confirmed adenoid cystic carcinoma (ACC) or colorectal carcinoma (CRC) that has relapsed or is no longer responding to treatment - Your cancer has progressed on prior therapies and at least one measurable tumor is visible on scans - You have not had major surgery, chemotherapy, or radiation therapy within the required time before starting the study - You are in adequate general health **You may NOT be eligible if...** - You have had major surgery within 28 days or chemotherapy within 14 days before starting - You have an active serious infection - You have another active cancer - You have significant heart disease Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGRGT-61159

Oral MYB inhibitor


Locations(10)

Dana-Farber Cancer Institute

Boston, Massachusetts, United States

University of Michigan

Ann Arbor, Michigan, United States

Washington University School of Medicine

St Louis, Missouri, United States

Laura & Isaac Perlmutter Cancer Center at NYU Langone Health

New York, New York, United States

Memorial Sloan Kettering Cancer Center

New York, New York, United States

MD Anderson Cancer Center

Houston, Texas, United States

Next Oncology VA

Fairfax, Virginia, United States

Fred Hutchinson Cancer Center

Seattle, Washington, United States

Ottawa Hospital Cancer Centre

Ottawa, Ontario, Canada

Princess Margaret Cancer Center

Toronto, Ontario, Canada

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT06462183


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