RecruitingPhase 2NCT06462378

Proton Therapy for Locally Advanced Cervical Cancer

Proton Therapy in Locally Advanced Cervical Cancer in Combination With Concomitant Chemotherapy and Brachytherapy


Sponsor

University of Aarhus

Enrollment

55 participants

Start Date

May 20, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this protocol is to determine toxicity and efficacy of proton therapy in combination with standard concomitant platinum-based chemotherapy and standard image-guided adaptive brachytherapy (IGABT) in patients with locally advanced cervical cancer (LACC). The over-all aim is to maintain a high disease control and at the same time reduce acute morbidity as well as late side effects after treatment.


Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 99 Years

Plain Language Summary

Simplified for easier understanding

This study tests whether proton therapy (a precise form of radiation therapy) can better protect healthy tissues compared to standard radiation in women with locally advanced cervical cancer who are treated with curative intent radiation and brachytherapy. **You may be eligible if...** - You are 18 or older with cervical cancer confirmed by biopsy (squamous, adenocarcinoma, or adenosquamous type) - Your cancer has spread to pelvic lymph nodes (FIGO stage IIIC1 with ≥3 involved nodes, or IIIC2) - Para-aortic lymph node involvement below a specific level is also eligible - You are in good enough health to receive definitive radiation therapy - You are able to understand Danish or the language of the treating center **You may NOT be eligible if...** - You have another primary cancer (except early-stage skin cancer) - Your cancer has spread beyond the para-aortic region - You have had previous pelvic or abdominal radiation - You are pregnant, breastfeeding, or at risk of pregnancy without adequate contraception - You have HIV Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

RADIATIONProton therapy

External beam proton therapy combined with standard cisplatin and brachytherapy


Locations(1)

Department of Oncology, Capital Region Denmark

Copenhagen, Denmark

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NCT06462378


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