OligoCare TwiCs (Trials Within Cohorts) Trial Comparing Acute Toxicity in Single-fraction vs Multiple-fraction SBRT for Metastasis-directed Treatment (SPRINT)

This trial compares delivering cancer-targeting radiation (SBRT — stereotactic body radiotherapy) in a single large dose versus multiple smaller doses for people with oligometastatic cancer (cancer with a limited number of spread sites). The goal is to find the safest and most effective approach. **You may be eligible if...** - You are already part of the OligoCare cohort study - All of your active cancer sites (primary tumor and metastases) were or will be treated with a goal of eliminating the cancer (radical intent) - All lesions planned for radiation are technically suitable for single-fraction SBRT - You have provided written informed consent **You may NOT be eligible if...** - Any of your target lesions are near sensitive structures such as the main airways, esophagus, spinal cord, or major digestive organs - Any metastasis is larger than 5 cm - Your doctor judges that single-fraction SBRT poses too high a risk for your specific lesion location Talk to your doctor to see if this trial is right for you.