RecruitingNCT06463366

Multi-parametric Magnetic Resonance Imaging for the Precise Diagnosis and Quantitative Study of Liver Steatosis, Inflammation, and Fibrosis in Chronic Liver Disease.


Sponsor

Shengjing Hospital

Enrollment

100 participants

Start Date

Jun 14, 2022

Study Type

OBSERVATIONAL

Conditions

Summary

To construct a novel, non-invasive, accurate, and convenient method to achieve the degree of liver damage is an important general problem in the management of patients with chronic liver disease. The investigators would like to develop non invasive advanced Magnetic Resonance Imaging (MRI) techniques (MR elastography, MRI-PDFF) to assess the degree of liver damage in patients with chronic liver disease. These techniques could reach high diagnostic performance for detection of liver fibrosis, inflammation and liver fat content; and could decrease the number of liver biopsies, which have risks and sample only a small portion of the liver.


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study evaluates whether advanced MRI techniques — specifically MR elastography and MRI-PDFF — can accurately assess the degree of liver damage (including fibrosis, inflammation, and fat content) in patients with chronic liver disease, potentially reducing the need for invasive liver biopsies. Researchers will follow participants every 6 months to see if changes in liver stiffness on MRI can predict how well treatments are working. Eligible participants are adults aged 18–75 with chronic liver disease (such as viral hepatitis, fatty liver, or cirrhosis) who are receiving standard treatment and have no contraindications to MRI, such as metal implants or pacemakers. Participation involves undergoing MRI scans at regular intervals alongside standard clinical care and lab tests. This summary was prepared using AI to help patients understand the study in plain language.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICE3D-MRE,MRI-PDFF

3D-MRE(storage modulus, ., loss modulus and damping ratio \[DR\] for liver inflammation and fibrosis) MRI-PDFF(liver fat content)


Locations(1)

Shengjing Hospital of China Medical University

Shenyang, Liaoning, China

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NCT06463366


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