Study on the Therapeutic Effect of Irinotecan Liposomes in Small Cell Lung Cancer

This study is testing whether a special form of chemotherapy called irinotecan liposome injections can help people with advanced (extensive stage) small cell lung cancer whose cancer came back or got worse after their first treatment. **You may be eligible if...** - You are 18 or older with extensive stage small cell lung cancer confirmed by tissue biopsy - Your cancer got worse after at least 6 months of first-line chemotherapy (with or without immunotherapy) containing platinum drugs - You have at least one measurable tumor on a scan - You are in reasonably good health (ECOG score 0-2) - Your blood counts, liver, and kidney function meet minimum levels - Your estimated survival is at least 3 months **You may NOT be eligible if...** - You have a mixed or large cell type of the cancer - You have active, uncontrolled brain metastases requiring high-dose steroids - You have serious heart problems (severe arrhythmia, recent heart attack, low heart pump function) - You have active hepatitis B, hepatitis C, or HIV - You are pregnant, breastfeeding, or unwilling to use contraception - You have another active cancer requiring treatment Talk to your doctor to see if this trial is right for you.