RecruitingPhase 2NCT06469970

Evolution of the Initial Distribution Volume of Glucose in the Severe Burned Adults

INDICIA: Evolution of the Initial Distribution Volume of Glucose in the Severe Burned Adults

Sponsor

Centre Hospitalier Régional Metz-Thionville

Enrollment

15 participants

Start Date

Nov 28, 2024

Study Type

INTERVENTIONAL

Conditions

Emergencies Burns Intensive Care

Summary

This is a prospective, observational, monocentric, phase II (exploratory) cohort study aiming to describe the evolutionary profile of the initial volume of glucose distribution (IDVG) during the first four days of management of severely burned patient.

Eligibility

Min Age: 18 Years

Inclusion Criteria7

Patients over 18 years of age
Patients hospitalized with burns of at least 30% of body surface area
By a thermal mechanism
At the CHR Metz-Thionville burn center
managed within the 8 hours post-burn
Patient affiliated to a social security scheme
Written consent obtained from the patient (or from the trusted person, family or relatives if the patient is unable to sign/express consent) or emergency inclusion if the patient is unable to express consent and neither the trusted support person nor any member of the family or relatives is present at the time of inclusion.

Exclusion Criteria10

Diabetic patients on insulin
Patient with a CONTRAINDICATION to GLUCOSE 30% PROAMP, solution for injection
Patients with pre-hospital cardiac arrest
extra corporeal circulation patient: Extra Corporeal Membranous Oxygenation (ECMO) or Extra Corporeal Life Support (ECLS) or CRRT (Continuous Renal Replacement Therapy)
patient without a central venous line or arterial catheter
Patient moribund or immediately subject to therapeutic limitation
Impossibility of trans-pulmonary thermodilution monitoring (vascular access difficulties)
Pregnant, parturient or breast-feeding women
Patient under guardianship, curatorship or safeguard of justice
Cognitive impairment or language barrier

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Interventions

DRUGGlucose 30% Intravenous Solution

Measurement of IDVG on admission, at 4 hours (H+4), and at 8, 16, 24, 48, 72 and 96 hours (H+8, H+16, H+24, H+48, H+72 and H+96) post-burn. The principle of this measurement consists of taking a reference blood glucose level measured on an arterial blood sample (arterial catheter) using a blood glucose meter. A bolus of 5g of glucose is injected into a central venous line over 30 seconds. A second blood glucose level is measured 3 minutes after the end of the injection. The intra-thoracic blood volume (ITBV) and extra-vascular lung water (EVLW) are measured using the PiCCO device as part of the usual management of burn patients.