UK CARDIOvascular Immune-Mediated Inflammatory Diseases (CARDIO-IMID) Registry Study

Inclusion Criteria23

• Written informed consent
• Diagnosis of an IMID by a rheumatologist with categorisation into one of the following:
• i. IMID-'higher risk' CVD: individuals who have a risk of developing CVD (based on traditional risk factors and/or IMID-specific factors) but no history of CVD
• Coronary artery disease (CAD): specifically, a high pre-test probability of CAD based on clinical risk factors (e.g. QRISK3 score ≥10%) and/or elevated biochemical markers (high-sensitivity C-reactive protein ≥2mg/L and/or Lipoprotein(a) ≥70mg/dL)
• Myopericardial involvement: Specific IMID and/or cardiovascular indicators that place at increased risk e.g. autoantibody associations, presence of peripheral myositis or other major organ involvement; incidental raised serum cardiac biomarkers (troponin and/or NT-pro BNP), on routine testing
• ii. Incident (new) IMID-CVD: Patients with IMID that present with a new history of CVD
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• ASCVD i. Major adverse cardiovascular events (MACE):
• \- Non-fatal myocardial infarction.
• \- Non-fatal stroke of any classification, including reversible focal neurologic
• \- Defects with imaging evidence of a new cerebral lesion consistent with ischemia or haemorrhage.
• ii. Other cardiovascular events not accounted for in the MACE-3 composite 2)a)i:
• \- Hospitalization for unstable angina
• \- Coronary revascularization
• \- Hospitalization for heart failure
• \- Transient Ischemic Attack (TIA)
• \- Peripheral Vascular Disease (PVD)
• Deep vein thrombosis (VTE) and/or pulmonary embolism \[PE\].
• Myopericardial involvement: as diagnosed by a cardiology specialist with 'tier 2' cardiovascular imaging and/or other clinical and biochemical criteria in line with usual care
• iii. Established IMID-CVD
• a) Patients with IMID and a history of past cardiovascular event as detailed in 2) a) above.
• b) Patients with a known history of myopericardial involvement as defined above in 2) b)
• Participants that receive a CMR scan as standard of care