Endoscopic Ultrasound (EUS) Intratumoral Injection of CAR-NK Cells in the Treatment of Advanced Pancreatic Cancer

This study tests whether CAR-NK cells (immune cells engineered to attack cancer) can be injected directly into pancreatic tumors using an endoscopic ultrasound-guided needle — a minimally invasive technique that avoids open surgery. The goal is to see if delivering these immune cells directly to the tumor is safe and effective. **You may be eligible if...** - You are between 18 and 75 years old - You have confirmed pancreatic ductal adenocarcinoma (the most common type of pancreatic cancer) - Your cancer is recurring, unresectable, or locally advanced (including cases where surgery is declined) - Your performance status is adequate (ECOG 0–1) **You may NOT be eligible if...** - Your cancer is resectable and you are fit for surgery and willing - Your expected survival is less than 3 months - You have severe organ or bone marrow problems Talk to your doctor to see if this trial is right for you.