Efficacy of Acetaminophen Alone Versus Combination of Acetaminophen/Ibuprofen After Cesarean Section
Efficacy of Intravenous Acetaminophen Alone Versus Combination of Acetaminophen/Ibuprofen (Maxigesic®IV) in Multimodal Analgesia After Cesarean Section: a Randomized Controlled Trial
Seoul National University Hospital
84 participants
Oct 9, 2024
INTERVENTIONAL
Conditions
Summary
The investigators aim to compare the analgesic efficacy of intravenous acetaminophen alone versus combination of acetaminophen/ibuprofen (Maxigesic®IV) in multimodal analgesia after cesarean section.
Eligibility
Inclusion Criteria2
- Patients scheduled for elective cesarean section
- Gestational age > 37+0 weeks
Exclusion Criteria11
- Emergency cesarean section
- Multiple pregnancy (e.g. twins, triplets)
- Body weight < 50 kg
- Preeclampsia
- History of hypersensitivity to acetaminophen or ibuprofen
- History of upper gastrointestinal tract bleeding or gastric ulcer
- Underlying liver disease
- Underlying kidney disease or GFR < 90 mL/min/1.73m2
- Heart failure or severe hypertension
- History of asthma
- Chronic use of barbital or tricyclic antidepressants
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Interventions
1g acetaminophen is administered during skin closure (end of operation).
A mixture of 1g acetaminophen and 300 mg ibuprofen (Maxigesic®IV) is administered during skin closure (end of operation)
1g acetaminophen is administered 6 hours after the first administration.
A mixture of 1g acetaminophen and 300 mg ibuprofen (Maxigesic®IV) is administered 6 hours after the first administration.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06479122