RecruitingNCT06480526

Feasibility of Screening for Early Late Effects of Contemporary Therapy in High-Risk Neuroblastoma Survivors

LEGACY (Late Effects of GD2 Antibody and Chemotherapy in Youths): Feasibility of Screening for Early Late Effects of Contemporary Therapy in High-Risk Neuroblastoma Survivors


Sponsor

St. Jude Children's Research Hospital

Enrollment

45 participants

Start Date

Oct 21, 2024

Study Type

OBSERVATIONAL

Conditions

Summary

The study participant is being asked to be in a research study called LEGACY, because you were treated for high-risk neuroblastoma (HR-NBL). Primary Objective To determine the feasibility of conducting comprehensive evaluations, leveraging the established SJLIFE (St. Jude Lifetime Cohort Study) study infrastructure, in survivors of HR-NBL (high-risk neuroblastoma) who are greater than 2 years from completion of contemporary therapy and were previously treated at SJCRH (St. Jude Children's Research Hospital). Exploratory Objectives * To describe the health outcomes of survivors of HR-NBL previously treated at SJCRH with contemporary era therapy who are greater than 2 years from completion of therapy. * To describe the relationship between patient outcomes and social determinants of health (SDOH) in survivors of HR-NBL previously treated at SJCRH with contemporary era therapy who are greater than 2 years from completion of therapy.


Eligibility

Min Age: 5 Years

Plain Language Summary

Simplified for easier understanding

This study is looking at the long-term health effects in children who survived high-risk neuroblastoma (a type of childhood cancer). Researchers want to screen survivors early for signs of health problems that can appear years after cancer treatment ends. **You may be eligible if...** - You were diagnosed with high-risk neuroblastoma before age 18 - You were treated at St. Jude Children's Research Hospital under a specific treatment protocol (NB2012) - It has been at least 2 years since you completed treatment - You are currently 5 years of age or older - You are enrolled in the SJLIFE study **You may NOT be eligible if...** - You or your legal guardian are unwilling to give written consent - You do not meet the treatment history or enrollment requirements listed above Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(1)

St. Jude Children's Research Hospital

Memphis, Tennessee, United States

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NCT06480526


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