RecruitingPhase 2NCT06483659
Intravenous Oxytocin for Post Operative Pain After Minimally Invasive Hysterectomy
Sponsor
Brigham and Women's Hospital
Enrollment
152 participants
Start Date
Jun 1, 2025
Study Type
INTERVENTIONAL
Conditions
Summary
This is a randomized, double-blinded, placebo-controlled trial to compare the effectiveness of IV oxytocin infusion to placebo on peri-operative opioid consumption and reducing post-operative pain following a minimally invasive hysterectomy under general anesthesia.
Eligibility
Sex: FEMALEMin Age: 18 YearsMax Age: 65 Years
Inclusion Criteria4
- Ages 18-65 years old
- ASA category 1-3
- Scheduled to undergo minimally invasive hysterectomy
- No documented allergy to oxytocin
Exclusion Criteria8
- American Society of Anesthesiologists (ASA) group 4 or greater
- Age >65 years old
- Additional surgical procedures including but not limited to minor laparotomy, omentectomy, cystectomy, vaginectomy, and/or ablation of endometriosis.
- Active opioid prescription of the equivalent of oxycodone >10 mg /day
- Opioid use disorder, including patients in treatment receiving naltrexone or Suboxone (Buprenorphine-naloxone)
- Allergies to any study medication: acetaminophen, celecoxib, ketorolac, fentanyl, hydromorphone, or oxycodone.
- Epidural/Regional anesthesia for intra-operative or post-operative pain.
- Inability to understand the questionnaires
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Interventions
DRUGOxytocin
Intravenous Oxytocin infusion
DRUGPlacebo
0.9% Saline
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06483659
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