Noninvasive Ventilation Facemasks Favoring Carbon Dioxide Washout
Physiological Effects of Novel Noninvasive Ventilation Facemasks Favoring Carbon Dioxide Washout in Patients With Hypercapnic Respiratory Failure
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
20 participants
Nov 15, 2024
INTERVENTIONAL
Conditions
Summary
The objective of this randomized cross-over trial is to assess the physiological effects of three different facemasks for noninvasive ventilation (Nivairo, Visairo, Optiniv) in patients with acute hypercapnic respiratory failure
Eligibility
Inclusion Criteria4
- Acute respiratory failure with
- PaCO2 ≥ 45 mmHg;
- Arterial pH \< 7.35;
- Signed written informed consent
Exclusion Criteria7
- Respiratory rate \< 12 bpm;
- Immediate need for intubation;
- Haemodynamic instability (Systolic blood pressure \<90 mmHg or mean arterial pressure \<65 mmHg) and/or lactic acidosis (lactate \>5 mmol/L) and/or clinically diagnosed shock;
- Metabolic Acidosis;
- Recent head surgery or anatomy that prevent the application of facemasks;
- Any contraindications to oesophageal balloon insertion and/or electrical impedance tomography (EIT) belt placement.
- Any contraindications to facemask noninvasive ventilation.
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Interventions
Respiratory support with a facemask connected to a ventilator through a heated humidifier. Ventilator will be set in the pressure support mode.
Locations(2)
View Full Details on ClinicalTrials.gov
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NCT06483984