Respiratory Insufficiency Clinical Trials

20 recruiting

Respiratory Insufficiency Trials at a Glance

24 actively recruiting trials for respiratory insufficiency are listed on ClinicalTrialsFinder across 6 cities in 20 countries. The largest study group is Not Applicable with 14 trials, with the heaviest enrollment activity in Toronto, Hamilton, and Baltimore. Lead sponsors running respiratory insufficiency studies include University Health Network, Toronto, University of Sao Paulo General Hospital, and Erasmus Medical Center.

Browse respiratory insufficiency trials by phase

Treatments under study

About Respiratory Insufficiency Clinical Trials

Looking for clinical trials for Respiratory Insufficiency? There are currently 20 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Respiratory Insufficiency trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Respiratory Insufficiency clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 24 trials

Recruiting
Not Applicable

Thoracoabdominal Asynchrony and Respiratory Distress

Respiratory Insufficiency
Massachusetts General Hospital20 enrolled1 locationNCT04626154
Recruiting

Comparison of Transcutaneous and Blood CO₂ Measurement in Critically Ill Children

Respiratory Insufficiency in Children
Brno University Hospital20 enrolled1 locationNCT07468006
Recruiting
Not Applicable

Platform of Randomized Adaptive Clinical Trials in Critical Illness

Respiratory InsufficiencyMechanical Ventilation Pressure HighExtracorporeal Membrane Oxygenation Complication
University Health Network, Toronto6,250 enrolled86 locationsNCT05440851
Recruiting
Not Applicable

Non-inferiority of Continuing Oral Intake Versus Fasting in Patients With Acute Respiratory Failure

AspirationRespiratory InsufficiencyDysphagia+2 more
University Hospital, Tours754 enrolled14 locationsNCT06510972
Recruiting

Registry for Automated Mechanical VEntilation in Adults

Respiratory Insufficiency Requiring Mechanical Ventilation
Hamilton Medical AG1,000 enrolled4 locationsNCT06655805
Recruiting
Not Applicable

Partial Neuromuscular Blockade in Acute Hypoxemic Respiratory Failure

Mechanical VentilationRespiratory InsufficiencyNeuromuscular Blockade
University Health Network, Toronto23 enrolled1 locationNCT04524585
Recruiting
Not Applicable

Combined Respiratory Training in Persons With ALS

ALSRespiratory InsufficiencyDysphagia
Nova Southeastern University34 enrolled1 locationNCT05913882
Recruiting

Multidimensional Characterization of Dyspnea in Children

Dyspnea and Respiratory Insufficiency in Children
Assistance Publique - Hôpitaux de Paris400 enrolled1 locationNCT05500833
Recruiting
Not Applicable

Pediatric Prehospital Airway Resuscitation Trial

Wounds and InjuriesChild, OnlyCritical Illness+2 more
Ohio State University3,000 enrolled10 locationsNCT06364280
Recruiting
Not Applicable

Noninvasive Ventilation Facemasks Favoring Carbon Dioxide Washout

Respiratory Insufficiency
Fondazione Policlinico Universitario Agostino Gemelli IRCCS20 enrolled2 locationsNCT06483984
Recruiting
Not Applicable

Multicenter HomeVENT: Home Values and Experiences Navigation Track

CommunicationPediatric ALLRespiratory Insufficiency
Johns Hopkins University600 enrolled4 locationsNCT06102330
Recruiting
Not Applicable

Effectiveness of Platform-Based Lateralization Therapy in Reducing Interface Pressure Between The Patient And The Support Surface

Respiratory Insufficiency
University of Sao Paulo General Hospital25 enrolled1 locationNCT06819943
Recruiting
Not Applicable

Home Versus Hospital Based NIV Care in MND

Motor Neurone DiseaseRespiratory Insufficiency
Papworth Hospital NHS Foundation Trust60 enrolled1 locationNCT06844370
Recruiting

Diaphragm Dysfunction and Ultrasound Perioperatively

PneumoniaRespiratory InsufficiencyTachypnea+2 more
Karolinska University Hospital160 enrolled2 locationsNCT05906030
Recruiting
Phase 2Phase 3

The Evaluation of the Effectiveness and Safety of Nalbuphine Hydrochloride Injection for Analgesia in ICU Patients: A Multicenter, Randomized, Single-blinded, Parallel, Two-step Trial

Respiratory Insufficiency
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology204 enrolled1 locationNCT06785571
Recruiting

Respiratory Functions, Thoracoabdominal Movements and Exercise Capacity in Neuromuscular Diseases

Duchenne Muscular DystrophyRespiratory InsufficiencySpinal Muscular Atrophy+3 more
Lokman Hekim University42 enrolled1 locationNCT06756633
Recruiting
Not Applicable

Feasibility of Reducing Respiratory Drive Using the Through-flow System

Lung InjuryRespiratory InsufficiencyDiaphragm Injury
University Health Network, Toronto15 enrolled1 locationNCT05642832
Recruiting
Phase 4

Comparing Anticoagulation Strategies Using UFH, Argatroban and LMWH for ECMO Support

BleedingThromboembolismRespiratory Insufficiency+1 more
Medical University of Vienna90 enrolled1 locationNCT06442267
Recruiting
Not Applicable

Comparison of Different Methods to Calculate Pendelluft by Electrical Impedance Tomography in Mechanically Ventilated Patients

Respiratory InsufficiencyARDSAsynchrony, Patient-Ventilator+1 more
University of Sao Paulo General Hospital15 enrolled1 locationNCT06494215
Recruiting

Respiratory Muscle Structure and Function in Mechanically Ventilated Patients and Long-term Outcomes

Mechanical Ventilation ComplicationLung InjuryRespiratory Insufficiency+2 more
University Health Network, Toronto230 enrolled1 locationNCT05857774