RecruitingNot ApplicableNCT06485986

Frontosubthalamic Networks in Parkinson's Disease.

Frontosubthalamic Network Dynamics and Their Modulation During Impulse Control and Decision Making in Parkinson's Disease


Sponsor

University of Oxford

Enrollment

20 participants

Start Date

Jun 1, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this experimental study with is to understand the underlying mechanisms behind the increase in impulsivity seen in some patients that undergo deep brain stimulation of the subthalamic nucleus for Parkinson's Disease. The main questions it aims to answer are: What are the distributed network effects of deep brain stimulation to the subthalamic nucleus? How does this correlate with increased impulsivity? Can alternative stimulation settings be used to minimize these? Participants will complete decision-making tasks whilst their deep brain stimulation devices are turned on and off with simultaneous magnetoencephalography recordings (a type of non-invasive brain scan that measures brain activity in real-time)


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating how the brain circuits involved in impulse control function differently in Parkinson's disease patients who have impulse control disorders (such as compulsive gambling or hypersexuality) compared to those who do not. It uses a specialized brain imaging technique called MEG. **You may be eligible if...** - You have been diagnosed with Parkinson's disease - You have had a brain stimulator (deep brain stimulation/DBS) implanted in the subthalamic nucleus as part of your care - You are willing and able to delay your morning Parkinson's medication by up to 4 hours for the study session - You are 18 or older **You may NOT be eligible if...** - You have a severe language barrier that prevents understanding study instructions - You have other implanted medical devices that could interfere with brain scanning - You have other neurological conditions besides Parkinson's disease - You are enrolled in another neurological clinical trial - You are unable to sit still in the brain scanner for the required duration Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERDBS on/off

DBS will be turned on and off for experimental periods to compare the effect of DBS on behaviour.


Locations(1)

John Radcliffe Hospital

Oxford, United Kingdom

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NCT06485986


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