Regional Assessment of the Risk of Lung Injury in Ventilated Patients
Regional Assessment of the Risk of Lung Injury in Ventilated Patients With Similar Lung Load
Hospital El Cruce
10 participants
Dec 1, 2023
OBSERVATIONAL
Conditions
Summary
Specific characteristics of the lung, such as its functional capacity, heterogeneity, and recruitment potential, can influence the development of ventilator-induced lung injury even under safe ventilation conditions. Objective: To evaluate the risk of ventilator-induced lung injury at the regional level in patients with acute respiratory distress syndrome ventilated with similar tidal volumes and inspiratory pressures.
Eligibility
Inclusion Criteria1
- \-
Exclusion Criteria7
- History of emphysema, asthma, pneumothorax, or active bronchopulmonary fistula.
- Severe instability at the time of the study defined by at least one of the following indicators: SaO2 ≤ 90%, shock requiring > 0.5 γ/kg/min of noradrenaline, complex arrhythmia, myocardial ischemia, intracranial hypertension refractory despite first-line measures.
- Esophageal pathology contraindicating esophageal balloon placement (esophageal varices, stenosis, trauma or esophageal surgery, tumor) and/or hematemesis.
- Severe coagulopathy (platelet count <20,000/mm3 or INR >4.
- Inability to undergo computed tomography: morbid obesity (>170 kg) or abdominal circumference >200 cm.
- Patients with do-not-resuscitate orders and pregnant women.
- Participation in another research study in the last 30 days.
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Interventions
Patients were ventilated under similar tidal volume, respiratory rate, and plateau pressure. PEEP was the adjustment variable to reach a similar plateau pressure
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06486259