Personalized Mechanical Ventilation Guided by UltraSound in Patients With Acute Respiratory Distress Syndrome

Acute Respiratory Distress Syndrome (ARDS) is a life-threatening condition where the lungs fill with fluid, making breathing very difficult. Patients need mechanical ventilation, but the right settings are not always clear. This ICU study uses lung ultrasound to personalize ventilator settings for each patient, with the goal of reducing lung injury from the ventilator itself. You may be eligible if: • You are 18 years old or older • You are admitted to an ICU and on invasive mechanical ventilation • You meet the Berlin criteria for moderate or severe ARDS You may NOT be eligible if: • Ultrasound of your lungs is not technically possible (e.g., subcutaneous emphysema, morbid obesity, or wounds) • You have been on a ventilator for more than 7 consecutive days in the past 30 days • You have had ARDS in the past month • Your BMI is above 40 • You have intracranial hypertension or a bronchopleural fistula • You are on ECMO • You have severe pulmonary fibrosis or end-stage lung disease • You were previously enrolled in the PEGASUS study Talk to your doctor to see if this trial is right for you.