Preoperative Use of Pantoprazole for Prevention of Post Operative Nausea and Vomiting in Gynecologic Surgery
United States Naval Medical Center, Portsmouth
132 participants
Aug 26, 2022
INTERVENTIONAL
Conditions
Summary
The goal of this clinical trial is to see if pantoprazole (a proton pump inhibitor used for acid reflux/heart burn) can reduce nausea and vomiting after gynecologic surgery in women between the ages of 18 and 79. Researchers will compare a placebo to the active medication. Participants will be asked to take three pills around their surgery, two taken before and one taken the night after.
Eligibility
Inclusion Criteria1
- Undergoing elective gynecological surgery by either an open abdominal or minimally invasive approach (to include both endoscopic and vaginal). Procedure must be performed under general anesthesia.
Exclusion Criteria7
- Pregnant,
- Patients with gastrointestinal disease requiring ongoing medical management.
- Prior gastrointestinal surgery with the exception of diagnostic procedures, appendectomy and cholecystectomy.
- Patients with a history of H2 receptor blocker use, proton pump inhibitor use or other GERD specific therapy within 30 days of surgery.
- Any patient identified by their surgical care team as having a history of PONV warranting additional perioperative prophylaxis.
- Known r suspected malignancy
- Lactose intolerance
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Interventions
Pantoprazole 40mg given the night before surgery, 2 hours prior to surgery, and the evening after surgery.
Placebo given the night before surgery, 2 hours prior to surgery, and the evening after surgery.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06488001