RecruitingPhase 2NCT06490081

Trilaciclib Prevents Myelosuppression With Chemoradiotherapy

To Evaluate the Protective Effect of Trilaciclib on Myelosuppression in Patients With Limited-stage Small Cell Lung Cancer Associated With Concurrent Chemoradiotherapy and Discuss the Effect of Gut Microbiota Changes on Myelosuppression


Sponsor

Cancer Institute and Hospital, Chinese Academy of Medical Sciences

Enrollment

40 participants

Start Date

Jun 26, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

To evaluate the protective effect of Trilaciclib on myelosuppression in patients with limited-stage small cell lung cancer associated with concurrent chemoradiotherapy and discuss the effect of gut microbiota changes on myelosuppression


Eligibility

Min Age: 40 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether a drug called trilaciclib can reduce bone marrow suppression (low blood cell counts) caused by chemoradiotherapy in people with limited-stage small cell lung cancer. Trilaciclib temporarily protects bone marrow cells from chemotherapy damage. **You may be eligible if...** - You have limited-stage small cell lung cancer (cancer confined to one side of the chest) - Your overall health is adequate for combined chemotherapy and radiation (ECOG 0–2) - Your organ function is in acceptable range **You may NOT be eligible if...** - You have brain metastases that require radiation or steroids - You have an active infection requiring systemic treatment - You are pregnant or breastfeeding - You have certain heart conditions or significant autoimmune diseases Talk to your doctor to see if this trial is right for you.

This is a simplified summary. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGTrilaciclib

During concurrent chemoradiotherapy in limited-stage small cell lung cancer, Trilaciclib is administered prophylactically before the first cycle of chemotherapy


Locations(1)

Cancer Hospital Chinese Academy of Medical Sciences

Beijing, Beijing Municipality, China

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NCT06490081


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