RecruitingPhase 2NCT06929936

Trilaciclib in Combination With Docetaxel for Second-Line and Beyond Treatment of Locally Advanced or Metastatic NSCLC

Phase II Clinical Trial of Trilaciclib in Combination With Docetaxel for Second-Line and Beyond Treatment of Locally Advanced or Metastatic Non-Small Cell Lung Cancer


Sponsor

The First Affiliated Hospital of Xiamen University

Enrollment

33 participants

Start Date

May 9, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This study is a prospective, single arm phase II study aimed at patients with locally advanced or metastatic non-small cell lung cancer undergoing second-line or beyond treatment. The aim is to evaluate the bone marrow protective effect of trilaciclib before docetaxel chemotherapy for locally advanced or metastatic NSCLC.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study tests whether adding a drug called trilaciclib (which protects bone marrow during chemotherapy) to a standard chemotherapy called docetaxel helps people with advanced (Stage IV) non-small cell lung cancer (NSCLC) who have already received prior treatment. **You may be eligible if...** - You are 18 years or older - You have Stage IV NSCLC that has not responded to or has progressed after at least one standard treatment - You have at least one measurable tumor - Your blood counts and organ function meet required levels - You are in reasonably good health **You may NOT be eligible if...** - You are pregnant or breastfeeding - Your cancer has not previously been treated with standard first-line therapy - Your organ function (liver, kidney, blood) does not meet required thresholds - You have an expected survival of less than 3 months Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGTrilaciclib combined with Docetaxel

Trilaciclib: 240 mg/m2 as a 30-min iv. infusion, completed ≤4h prior to chemotherapy. Docetaxel: 75mg/m2, iv. infusion for 1 hour on days 1 of each 21-day cycle, totaling 4 cycles of medication.


Locations(1)

The First Affiliated Hospital of Xiamen University

Xiamen, Fujian, China

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NCT06929936


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