Treatment of Chronic Obstructive Pulmonary Disease by Infusion of Allogenic Mesenchymal Stem Cells

This study is testing intravenous infusions of stem cells (called mesenchymal stem cells, donated from healthy people) in people with moderate to severe COPD (chronic obstructive pulmonary disease). Researchers hope these stem cells can reduce inflammation and potentially slow lung function decline. **You may be eligible if...** - You are 40 to 80 years old with a confirmed COPD diagnosis - Your lung function test shows a FEV1 between 30% and 80% of normal - You have significant breathlessness and your disease has been stable for at least 3 months - You are a current or former smoker with at least 10 pack-years of smoking history **You may NOT be eligible if...** - You have had a COPD flare-up requiring hospitalization in the past 3 months - You have cancer or active autoimmune disease - You have severe heart, liver, or kidney problems - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.