2 Courses of Concurrent Cisplatin Chemoradiotherapy After Surgery for High-risk Head and Neck Squamous Cell Carcinoma

This study is testing whether giving only 2 cycles of cisplatin chemotherapy alongside radiation therapy (instead of the more common 3 cycles) after surgery is an effective and less toxic option for people with high-risk head and neck squamous cell carcinoma. High-risk means the cancer had spread to lymph nodes beyond the capsule, or the surgical margins were not clear. **You may be eligible if...** - You have had surgery for stage III or IV head and neck squamous cell carcinoma - Your pathology showed high-risk features (cancer beyond lymph node capsule or positive/close surgical margins) - Your cancer has not spread to distant parts of the body - Your general health and blood counts are adequate (Karnofsky score above 70) **You may NOT be eligible if...** - Your cancer has spread to distant organs (metastasis) - You have severe kidney, liver, or bone marrow dysfunction - You have already received prior radiation to the head and neck - You are pregnant Talk to your doctor to see if this trial is right for you.