RecruitingNCT06492538

Biometric Changes After Intervention of Anterior Chamber Angle : an Observational Study

Sponsor

Zhongshan Ophthalmic Center, Sun Yat-sen University

Enrollment

300 participants

Start Date

Dec 1, 2023

Study Type

OBSERVATIONAL

Conditions

Glaucoma Angle-Closure Glaucoma Goniotomy Minimally Invasive Glaucoma Surgery Goniosynechialysis

Summary

The drainage angle in the anterior chamber of the eye mediates the outflow of aqueous humor, and pathological changes here can lead to high intraocular pressure and glaucoma. Minimally invasive glaucoma surgery, particularly angle surgery, has advanced recently, allowing clear visualization of angle structures like the trabecular meshwork and Schlemm's canal using surgical goniolens. Techniques for angle intervention include widening the angle, reopening closed angles, and rebuilding outflow pathways using methods such as laser peripheral iridotomy, Argon laser peripheral iridoplasty, and mechanical separation of adhered tissues. Our research team plans to conduct imaging studies to track the healing of angle tissues post-surgery, aiming to support innovation and standardization of minimally invasive angle surgery.

Eligibility

Min Age: 30 YearsMax Age: 85 Years

Plain Language Summary

Simplified for easier understanding

This observational study is measuring changes in eye anatomy (using specialized imaging tools) before and after surgical procedures for glaucoma that target the drainage angle of the eye (such as laser treatments, trabeculotomy, or combined surgeries with lens removal). Researchers want to better understand how these surgeries change eye structures. **You may be eligible if...** - You have glaucoma and are scheduled for a standalone or combined angle surgery (such as laser peripheral iridotomy, goniosynechialysis, trabeculotomy, or cataract surgery combined with glaucoma surgery) - You are able to undergo specialized pre-operative eye imaging - You agree to follow-up visits and sign the consent form **You may NOT be eligible if...** - You have serious eye conditions such as corneal infection, ulcer, trauma, or eye tumors - You are unable to undergo the required imaging or follow-up visits Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREvarious types of angle interventions

procedures include laser peripheral iridotomy (LPI) to relieve pupillary tissue and deepen peripheral anterior chamber depth, Argon laser peripheral iridoplasty (ALPIp) to stimulate iris contraction and widen the angle, and mechanical separation of adhered angle tissues using instruments like goniosynechialysis hooks or iris repositor. Ab interno goniotomy using instruments like retina hooks, trabeculectomy hooks, or cannulas are used to incise trabecular meshwork and Schlemm's canal walls to enhance aqueous humor outflow.