Modular Trial of sEphB4-HSA in EphrinB2-High Solid Tumors

This trial is testing a drug called sEphB4-HSA in people with solid tumors (cancers in organs or tissues) that have high levels of a protein called EphrinB2, which the drug targets to block tumor growth. **You may be eligible if...** - You are 18 or older and have an advanced solid tumor that has not responded to standard treatment - Your tumor has been tested and shows high levels of EphrinB2 - You are in reasonably good physical condition - You are able to provide tumor tissue for analysis **You may NOT be eligible if...** - Your tumor does not express EphrinB2 - You have not had your tumor molecularly profiled - You have uncontrolled or active brain metastases - You have serious ongoing infections, significant heart problems, or other conditions that would make participation unsafe - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.