RecruitingPhase 1NCT06494371

A Study of LCAR-HL30 in Subjects With Relapsed/Refractory Hodgkin's Lymphoma and Anaplastic Large Cell Lymphoma

An Open-label Clinical Study to Evaluate the Safety, Tolerability, and Efficacy of CD30-Targeted LCAR-HL30 Cells in Patients With Relapsed/Refractory Hodgkin's Lymphoma and Anaplastic Large Cell Lymphoma


Sponsor

Ruijin Hospital

Enrollment

32 participants

Start Date

Jul 1, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

This is a prospective, single-arm, open-label, exploratory clinical study of LCAR-HL30 in adult subjects with relapsed/refractory Hodgkin's Lymphoma and Anaplastic Large Cell Lymphoma.


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This trial is testing an experimental cell therapy called LCAR-HL30 — a type of CAR-T therapy targeting a protein called CD30 — in people with Hodgkin's lymphoma or a related blood cancer called anaplastic large cell lymphoma (ALCL) that has relapsed or stopped responding to treatment. **You may be eligible if...** - You are 18–75 years old - You have been diagnosed with Hodgkin's lymphoma or anaplastic large cell lymphoma that is CD30-positive - Your cancer has come back or is no longer responding to prior treatments - You are in reasonably good physical condition (ECOG 0–1 in dose escalation; up to 2 in expansion) - Your expected survival is at least 3 months **You may NOT be eligible if...** - You have active brain involvement of your lymphoma - You have had a prior allogeneic stem cell transplant - You have serious organ dysfunction, active infection, or autoimmune disease - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALLCAR-HL30 cells

Prior to infusion of the LCAR-HL30, subjects will receive a conditioning premedication regimen consisting of cyclophosphamide and fludarabine


Locations(1)

Ruijin Hospital, Shanghai Jiao Tong University School of Medicine

Shanghai, China

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NCT06494371


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