Intravenous Vesicular Stomatitis Virus in Patients With Peripheral T-cell Lymphoma
MC1684 Phase I Trial of Systemic Administration of Vesicular Stomatitis Virus Genetically Engineered to Express NIS and Human Interferon, in Patients With Relapsed or Refractory Multiple Myeloma, Acute Myeloid Leukemia, Lymphomas, or Histiocytic/Dendritic Cell Neoplasms
Mayo Clinic
21 participants
Jan 5, 2024
INTERVENTIONAL
Conditions
Summary
This phase I trial studies the best dose and side effects of recombinant vesicular stomatitis virus (VSV) carrying the human (h) sodium iodide symporter (NIS) and Interferon (IFN) beta (β) genes (VSV-hIFNβ-NIS) in combination with ipilimumab and cemiplimab in patients with T-cell lymphoma. A virus, called VSV-hIFNβ-NIS, which has been changed in a certain way, may be able to kill cancer cells without damaging normal cells. Immunotherapy with ipilmumab and cemiplimab may induce changes in body's immune system and may interfere with the ability of tumor cells to grow and spread.
Eligibility
Plain Language Summary
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Interventions
Undergo tumor biopsy
Undergo blood sample collection
Undergo bone marrow biopsy
Undergo SPECT/CT
Undergo PET scan
Given IV
Undergo SPECT/CT
Given IV
Given IV
Locations(2)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06508463