RecruitingNot ApplicableNCT06495658

Impact of Prebiotics in Ulcerative Colitis

The Clinical and Microbial Impact of Prebiotics in Ulcerative Colitis

Sponsor

University of California, Los Angeles

Enrollment

70 participants

Start Date

Jul 9, 2024

Study Type

INTERVENTIONAL

Conditions

Crohn Disease Ulcerative Colitis

Summary

The cause of inflammatory bowel disease (IBD) is currently unknown, although partly attributed to interactions among genetic risk polymorphisms, environmental factors, gut microbiome, and host immunity. Diet, particularly those with plant-based products, have been shown in prior research to improve gut microbial composition, which has been linked to different IBD-related outcomes. This study is interested in evaluating the impact of prebiotics on gut microbiome composition and gut health in patients with IBD. Dietary composition will be assessed at baseline and over the course of 16 weeks. Participants will be randomized to either consume an 8-week course of prebiotic supplementation beginning at week 0 or week 8. Stool samples will be collected at weeks 0 and 8. The stool will be analyzed for cross-sectional and longitudinal fecal microbial changes associated with different prebiotic and diet consumption patterns in the context of heterogeneous disease characteristics.

Eligibility

Min Age: 18 YearsMax Age: 85 Years

Plain Language Summary

Simplified for easier understanding

This trial is testing whether adding prebiotic supplements (which feed healthy gut bacteria) can reduce inflammation and improve symptoms in people with active ulcerative colitis, a type of inflammatory bowel disease. **You may be eligible if...** - You are 18–85 years old - You have a confirmed history of ulcerative colitis (proven by biopsy) - You currently have active symptoms (SCCAI score above 2) - You may continue your existing medications (5-ASA, immune modulators, biologics) as long as doses have been stable for 30–60 days **You may NOT be eligible if...** - You have Crohn's disease or another form of inflammatory bowel disease - Your medications were started or adjusted within the past 30–60 days - You have severe complications such as bowel obstruction or perforation - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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