Pulmonary Artery DenerVation Clinical Study Using the Gradient Denervation System in Heart Failure Patients With Pulmonary Hypertension Group 2 (PreVail-PH2 OUS Study)

This trial is testing a catheter-based procedure called pulmonary artery denervation — which disrupts overactive nerve signals in the lungs — in people with heart failure complicated by high blood pressure in the lungs (pulmonary hypertension), to see if it can improve heart and lung function. **You may be eligible if...** - You have heart failure with elevated pressure in your lung arteries (mean pulmonary artery pressure above 20 mmHg) - Your pulmonary vascular resistance is 3 or more units and your wedge pressure is above 15 mmHg - Your symptoms are NYHA Class II or III (moderate impairment) - Your kidney function is adequate (GFR at least 25 ml/min) **You may NOT be eligible if...** - You have severe valve disease (aortic or mitral) - Your life expectancy is less than 2 years - You cannot tolerate blood-thinning medications or right heart catheterization - You have had a recent heart attack or cardiac surgery Talk to your doctor to see if this trial is right for you.