RecruitingPhase 2NCT06496607

A Study to Evaluate Solriktug in Adult Participants With Asthma

A Phase 2, Randomized, Double-blind, Placebo-controlled, Multiple Dose-Ranging Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Solrikitug in Adult Participants With Asthma (RAINIER)

Sponsor

Uniquity One (UNI)

Enrollment

140 participants

Start Date

Jul 26, 2024

Study Type

INTERVENTIONAL

Conditions

Asthma

Summary

Phase 2 study to evaluate the safety, tolerability, PK, immunogenicity, and pharmacodynamics of solriktug with adult participants with asthma.

Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a new drug called solriktug (also called MEDI3506) to see if it can improve asthma control in adults whose symptoms are not well-managed despite being on standard inhaler medications. **You may be eligible if...** - You are between 18 and 75 years old with a confirmed asthma diagnosis for at least 12 months - You are currently taking an inhaled corticosteroid (ICS) plus a long-acting beta agonist (LABA), or a triple therapy inhaler - Your asthma symptoms are still poorly controlled (ACQ-6 score ≥ 1.5) - You meet lung function and blood test criteria at screening **You may NOT be eligible if...** - You have COPD, active smoking history above a certain level, or other serious lung conditions - You have recently used systemic (oral/injected) steroids - You have certain heart, immune, or other serious medical conditions - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALNSI-8226

Solrikitug

BIOLOGICALNSI-8226

Solrikitug

BIOLOGICALNSI-8226

Solrikitug

BIOLOGICALPlacebo

Placebo

Locations(74)

Velocity Clinical Research

Mobile, Alabama, United States

Phoenix Medical Group

Peoria, Arizona, United States

Warren W. Pleskow, M.D.

Encinitas, California, United States

Beach Physicians Clinical Research Corp.

Huntington Beach, California, United States

Biosolutions Clinical Research Center

La Mesa, California, United States

Orso Health

Long Beach, California, United States

Downtown LA Research Center

Los Angeles, California, United States

Newport Native MD, Inc.

Newport Beach, California, United States

Prospective Research Innovations Inc.

Rancho Cucamonga, California, United States

Allergy & Asthma Medical Group and Research Center

San Diego, California, United States

Allergy & Asthma Associates of Santa Clara Valley

San Jose, California, United States

San Jose Clinical Trials

San Jose, California, United States

North Bay Clinical Research

Santa Rosa, California, United States

Providere Research

West Covina, California, United States

Velocity Clinical Research - Denver

Englewood, Colorado, United States

Clinical Research of West Florida

Clearwater, Florida, United States

JY Research Institute

Cutler Bay, Florida, United States

Hillcrest Medical Research, LLC

DeLand, Florida, United States

Clinical Site Partners LLC dba-Leesburg

Leesburg, Florida, United States

Pharmax Research of South Florida

Miami, Florida, United States

Coral Research Clinic Corp.

Miami, Florida, United States

Pro-Care Research Center, Corp.

Miami Gardens, Florida, United States

Ogden Clinical Canyon View

Tallahassee, Florida, United States

Care Access, Tamarac

Tamarac, Florida, United States

TBC Research

Tamarac, Florida, United States

National Clinical Trials

Cordele, Georgia, United States

CPCC - Research, LLC

East Point, Georgia, United States

Aeroallergy Research Laboratories of Savannah, Inc.

Savannah, Georgia, United States

NexGen Research

Boise, Idaho, United States

Treasure Valley Medical Research

Boise, Idaho, United States

Velocity Clinical Research - Boise

Meridian, Idaho, United States

Accellacare - Duly

Winfield, Illinois, United States

Indiana Medical Research Institute

Merrillville, Indiana, United States

Velocity Clinical Research - Sioux City

Sioux City, Iowa, United States

Velocity Clinical Research

Lafayette, Louisiana, United States

Chesapeake Clinical Research, Inc.

White Marsh, Maryland, United States

Mayflower Clinical

South Dartmouth, Massachusetts, United States

Deerborn Clinic

Dearborn, Michigan, United States

Henry Ford Health System

Detroit, Michigan, United States

Pulmonary Research Institute of SE Michigan

Farmington Hills, Michigan, United States

Revive Research Institute, Inc.

Southfield, Michigan, United States

Montana Medical Research, Inc.

Missoula, Montana, United States

Henderson Trials

Henderson, Nevada, United States

A1 Clinical

Queens Village, New York, United States

Asheville Clinical Research

Asheville, North Carolina, United States

Clinical Research of Gastonia

Gastonia, North Carolina, United States

North Carolina Clinical Research

Raleigh, North Carolina, United States

Southeastern Research Center

Winston-Salem, North Carolina, United States

Midwest Clinical Research

Dayton, Ohio, United States

Toledo Institute of Clinical Research Inc.

Toledo, Ohio, United States

OK Clinical Research

Edmond, Oklahoma, United States

Velocity Clinical Research

Medford, Oregon, United States

Northwest Research Center

Portland, Oregon, United States

Clinical Research Associates of Central PA

DuBois, Pennsylvania, United States

Allergy & Asthma Diagnostic Treatment Center

Lancaster, Pennsylvania, United States

Temple University - Shenoy

Philadelphia, Pennsylvania, United States

Care Access - Mauldin

Mauldin, South Carolina, United States

Allergy, Asthma & Sinus Center, LLC

Myrtle Beach, South Carolina, United States

MBR - Charleston

North Charleston, South Carolina, United States

Clinical Research of Rock Hill

Rock Hill, South Carolina, United States

Premier Research Center, LLC

Hendersonville, Tennessee, United States

New Phase Research & Development

Knoxville, Tennessee, United States

TTS Research

Boerne, Texas, United States

Proactive RGV

Brownsville, Texas, United States

Ten20 Clinical Research, LLC

Carrollton, Texas, United States

Javarra Research

Conroe, Texas, United States

Dallas Allergy and Asthma Center

Dallas, Texas, United States

IntraCare Health Center

Dallas, Texas, United States

US Allergy & Asthma

Frisco, Texas, United States

IntraCare Clinical

Greenville, Texas, United States

Axsendo Clinical Research

Houston, Texas, United States

Gulf Coast Clinical Research

Houston, Texas, United States

Baylor Scott & White Health

Temple, Texas, United States

Velocity Clinical Research - Hampton

Hampton, Virginia, United States

View Full Details on ClinicalTrials.gov

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NCT06496607

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