RecruitingPhase 1NCT04624490

Hyperpolarized 129Xe MR Imaging of Lung Function in Healthy Volunteers and Subjects With Pulmonary Disease

Sponsor

Mario Castro, MD, MPH

Enrollment

260 participants

Start Date

Nov 2, 2020

Study Type

INTERVENTIONAL

Conditions

Asthma COPD Cystic Fibrosis Interstitial Lung Disease Pulmonary Hypertension Pulmonary Infection Other Lung Disease

Summary

The purpose of this study is to develop and evaluate the usefulness of hyperpolarized (HP) 129Xe gas MRI for regional assessment of pulmonary function.

Eligibility

Min Age: 3 Years

Inclusion Criteria7

Healthy Volunteers:
Subject has no diagnosed pulmonary conditions
Ability to read and understand English or Spanish
Subjects with Lung Disease:
Subject has a diagnosis of pulmonary dysfunction made by a physician
No acute worsening of pulmonary function in the past 30 days
Ability to read and understand English or Spanish

Exclusion Criteria8

MRI is contraindicated based on responses to MRI screening questionnaire
Subject is pregnant or lactating
Subject does not fit into 129Xe vest coil used for MRI
Subject cannot hold his/her breath for 15-16 seconds
Subject deemed unlikely to be able to comply with instructions during imaging
Oxygen saturation \<88% on room air or with supplemental oxygen
Cognitive deficits that preclude ability to provide consent
Institutionalization

Interventions

DRUGHyperpolarized Xe129

During MRI scanning, subject will inhale hyperpolarized xenon gas for a maximum of 16 seconds per scan, with a maximum of 4 MR scans + Calibration in a given imaging session.

Locations(1)

University of Kansas Medical Center

Kansas City, Kansas, United States

View Full Details on ClinicalTrials.gov

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NCT04624490

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