RecruitingPhase 1NCT04624490

Hyperpolarized 129Xe MR Imaging of Lung Function in Healthy Volunteers and Subjects With Pulmonary Disease

Sponsor

Mario Castro, MD, MPH

Enrollment

260 participants

Start Date

Nov 2, 2020

Study Type

INTERVENTIONAL

Conditions

Asthma COPD Cystic Fibrosis Interstitial Lung Disease Pulmonary Hypertension Pulmonary Infection Other Lung Disease

Summary

The purpose of this study is to develop and evaluate the usefulness of hyperpolarized (HP) 129Xe gas MRI for regional assessment of pulmonary function.

Eligibility

Min Age: 3 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a new type of MRI that uses hyperpolarized xenon gas (a safe inhaled gas) to take detailed pictures of how the lungs are working. The goal is to develop better tools for diagnosing and monitoring lung diseases. **You may be eligible if...** - You are a healthy volunteer with no lung conditions, OR - You have been diagnosed with a lung disease by a doctor - You can read and understand English or Spanish - You can hold your breath for 15–16 seconds **You may NOT be eligible if...** - MRI is not safe for you (e.g., you have certain metal implants) - You are pregnant or breastfeeding - Your blood oxygen level is dangerously low even with supplemental oxygen - You have significant cognitive difficulties making it hard to follow instructions during the scan - You do not fit into the specialized vest used for the MRI Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGHyperpolarized Xe129

During MRI scanning, subject will inhale hyperpolarized xenon gas for a maximum of 16 seconds per scan, with a maximum of 4 MR scans + Calibration in a given imaging session.