RecruitingPhase 4NCT06497660

Effect of Neoadjuvant Chemotherapy on Cardiac Function of Perioperative Patients With Breast Cancer and New Strategies for Anesthesia

Effect of Neoadjuvant Chemotherapy on Cardiac Function of Perioperative Patients With Breast Cancer and New Strategies for Anesthesia Response: a Multicenter, Prospective, Randomized, Controlled Study


Sponsor

Fujian Medical University Union Hospital

Enrollment

496 participants

Start Date

Aug 1, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

As is well known, perioperative hemodynamic fluctuations, such as decreased blood pressure and heart rate, and cardiac dysfunction, are common complications after anesthesia. General anesthetics such as propofol and sufentanil can inhibit the central nervous system, reduce cardiac excitability and myocardial contractility, dilate peripheral blood vessels, and have a high incidence of hypotension, especially during anesthesia induction, which is particularly common in the elderly and those with underlying underlying diseases before surgery. However, the current research on the impact of neoadjuvant chemotherapy on perioperative cardiac function in patients is not specific, and there is no unified anesthesia strategy for these effects during the perioperative period. Therefore, this study aims to explore: 1. the effect of neoadjuvant chemotherapy on perioperative cardiac function in patients; 2. Improve the anesthesia plan and further explore new strategies for perioperative organ protection for such patients. The research design is a prospective, randomized, controlled trial.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating how chemotherapy given before breast cancer surgery (called neoadjuvant chemotherapy) affects the heart, and whether different anesthesia strategies during surgery can protect heart function. **You may be eligible if...** - You are 18 or older and undergoing surgery for breast cancer after neoadjuvant chemotherapy - Your heart pumping function (ejection fraction) is at least 45% before chemo and at least 40% after - Your heart rhythm is normal (sinus rhythm on ECG) - You can understand and cooperate with the study **You may NOT be eligible if...** - You have a known heart condition such as congenital heart disease, arrhythmia requiring treatment, heart valve problems, or cardiomyopathy - You have a high-degree heart block - You have other serious conditions that make you unsuitable for the study Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGDeoxyadrenaline

Deoxyadrenaline is a vasoactive drug

DRUGnormal saline

Deoxyadrenaline is a vasoactive drug


Locations(1)

Fujian Medical University Affiliated Union Hospital

Fuzhou, Fujian, China

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NCT06497660


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