RecruitingNot ApplicableNCT06501495

Links Between Cognitive Deficits During Normal or Pathological Aging and Slow Waves Measured in EEG

Slow Waves During Sleep and Wakefulness: a Common Denominator for Cognitive and Attentional Disorders in Normal and Pathological Aging (Exploratory Study)


Sponsor

Assistance Publique - Hôpitaux de Paris

Enrollment

90 participants

Start Date

Apr 24, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

With age, memory processes (encoding, consolidation and retrieval) as well as daytime vigilance are altered. Sleep is also impaired in older adults, notably slow waves that are known to play a key role in memory consolidation. Interestingly, some slow waves can also be detected in EEG recordings during wakefulness, and have been related to vigilance fluctuations. The investigators believe that slow waves, during both sleep and wakefulness, could constitute a common biomarker of sleep disturbances and daytime vigilance problems. A dysregulation of slow waves could thus explain the impact of aging on the different memory processes. Since alterations in memory capacity, attention, and sleep quality are further exacerbated in patients with Alzheimer's disease (AD), the investigators propose to study the links between aging (normal and pathological), sleep and daytime vigilance alterations, and their impacts on the different key stages of memory. The investigators will examine the associations between slow waves and changes in memory and vigilance in normal and pathological aging by studying young adults, seniors without cognitive disorders, and patients with prodromal AD. By replaying sensory cues associated with learning material during sleep, the investigators will also evaluate the effectiveness of auditory stimulation during sleep to enhance memory consolidation in older adults without and without cognitive deficits. Overall, this study aims to better understand the relationships between slow waves, aging, memory, and vigilance, providing insights into cognitive decline and potential interventions in aging and Alzheimer's disease.


Eligibility

Min Age: 18 YearsMax Age: 85 Years

Plain Language Summary

Simplified for easier understanding

This study uses brain monitoring (EEG, which measures electrical activity in the brain) to explore how slow brain waves during sleep are linked to memory and thinking problems that occur in normal aging, early Alzheimer's disease, and in healthy young adults. Participants are placed into three groups for comparison. **You may be eligible if...** - You are a native French speaker and completed at least 7 years of schooling - You are affiliated with a social security system - As a patient group participant: you are aged 60–85 with early Alzheimer's disease (prodromal stage) confirmed by clinical features and spinal fluid markers - As a healthy older adult: you are aged 60–85 with no cognitive impairment - As a young adult: you are aged 18–35 with no cognitive impairment **You may NOT be eligible if...** - (Criteria are largely defined by group membership and cognitive screening scores; those not fitting one of the three groups above, or with significant cognitive impairment in the control groups, would not qualify) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERvideo polysomnography

video polysomnography during 2 nights

OTHERAttention task

Attention task : SART Test (Sustained Attention to Response Task)


Locations(1)

Maladies du Sommeil

Paris, France

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NCT06501495


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