RecruitingNCT06502015

Biomarkers in Autoimmune Disease of Nervous System

Biomarkers of Neurological Autoimmune Diseases


Sponsor

Tongji Hospital

Enrollment

50,000 participants

Start Date

Jul 31, 2024

Study Type

OBSERVATIONAL

Conditions

Summary

Neurological autoimmune diseases are a group of disorders characterized by the abnormal immune response attacking the nervous system, including the brain, spinal cord and peripheral nerves. These diseases exhibit high heterogeneity, diverse clinical presentations, and are challenging to diagnose and manage due to a lack of effective treatments. In this study, the investigators will recruit eight kinds of autoimmune diseases of nervous system including Neuromyelitis Optica Spectrum Disorder (NMOSD), Myasthenia Gravis (MG), Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP), idiopathic inflammatory myopathy (IIM), and multiple sclerosis (MS), autoimmune encephalitis (AE), Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD). Through this study, the investigators aim to discover biomarkers with high sensitivity, specificity, and stability, which can support early diagnosis, disease monitoring, and personalized treatment for neurological autoimmune diseases, thereby improving the quality of life and prognosis for patients.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is collecting blood and biological samples from people with autoimmune diseases of the nervous system to identify biomarkers that could help with earlier diagnosis and better understanding of these conditions. Healthy volunteers are also needed for comparison. **You may be eligible if...** - You have been diagnosed with one of the following autoimmune neurological conditions: neuromyelitis optica spectrum disorder (NMOSD), myasthenia gravis, CIDP, inflammatory muscle disease, multiple sclerosis, autoimmune encephalitis, MOGAD, or similar conditions - You are a healthy individual matched for age and sex (for the control group) **You may NOT be eligible if...** - You have a known primary immune deficiency - You have a severe brain, lung, or systemic infection - Your neurological symptoms are caused by a secondary condition such as lupus or vasculitis - You have a blood vessel disease, hereditary metabolic condition, brain tumor, or toxic cause for your neurological symptoms - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTbiomaker levels

this study will discover and validate novel biomarkers (including blood, feces, bone marrow and lymph nodes etc al) of various neurological autoimmune diseases


Locations(1)

Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology

Wuhan, China

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NCT06502015


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