Study of ALTO-101 in Patients With Schizophrenia

This study tests a new drug called ALTO-101 in people with schizophrenia who are experiencing cognitive impairment (problems with memory and thinking) despite being on stable antipsychotic medications. **You may be eligible if...** - You have been diagnosed with schizophrenia for at least one year - You are experiencing cognitive difficulties related to your condition - You have been on stable doses of 1–2 antipsychotic medications for at least 8 weeks - Your psychotic symptoms are relatively stable (not in an acute flare) - Your BMI is between 18 and 37 - You are willing to comply with all study requirements **You may NOT be eligible if...** - You have an unstable medical condition - You were hospitalized for psychiatric reasons in the past 6 months - You have schizoaffective disorder, bipolar disorder, dementia, or intellectual disability - You are currently experiencing a major depressive episode - You are taking a mood stabilizer, clozapine, or daily benzodiazepines - You have a moderate or severe substance use disorder Talk to your doctor to see if this trial is right for you.