RecruitingPhase 2NCT06511063

Antiviral Clinical Trial for Long Covid-19

Investigating the Feasibility of Repurposing HIV Antivirals in Adults With Long Covid


Sponsor

Icahn School of Medicine at Mount Sinai

Enrollment

90 participants

Start Date

Oct 1, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The trial will test if two repurposed HIV antivirals can reduce symptom burden in adult participants with Long Covid compared to placebo. Viral infection and viral reactivation have been documented in Long Covid. Participants will be randomly allocated to receive antivirals, Truvada (tenofovir disoproxil/emtricitabine, TDF/FTC, Group 1) or Selzentry (Group 2), or a placebo (pill) (Group 3), taken daily for 90 days.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This antiviral clinical trial is testing whether antiviral medications can reduce symptoms and improve quality of life for people living with Long COVID — the condition where symptoms like fatigue, brain fog, headaches, and breathlessness persist for months after a COVID-19 infection. **You may be eligible if...** - You are 18 years or older, any gender - You have an official Long COVID diagnosis from a physician - You had a confirmed or suspected COVID-19 infection at least 6 months ago - You have been experiencing Long COVID symptoms (such as headache, memory problems, fatigue, shortness of breath, or loss of smell/taste) for at least 6 months - You are willing to comply with all study procedures for the duration of the trial **You may NOT be eligible if...** - Your Long COVID symptoms have been present for less than 6 months - You do not have a formal diagnosis of Long COVID from a doctor - You have certain medical conditions or are taking medications that are incompatible with the study drug Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGtenofovir disoproxil/emtricitabine

Participants will take Truvada (TDF/FTC, tenofovir disoproxil/emtricitabine) for 90 days.

DRUGSelzentry

Participants will take Selzentry for 90 days.

DRUGPlacebo

Matching placebo.


Locations(1)

The Cohen Center for Recovery from Complex Chronic Illnesses (CoRE)

New York, New York, United States

View Full Details on ClinicalTrials.gov

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NCT06511063


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