RecruitingNCT06511804

Correlation Between Noninvasive Blood Vessel Functionality Parameters and Cerebral Hemodynamics in Neurocritical Care Patients

Sponsor

University of Louisville

Enrollment

25 participants

Start Date

Nov 17, 2024

Study Type

OBSERVATIONAL

Conditions

Brain Injuries Intracranial Pressure Increase Monitoring

Summary

The purpose of this clinical research project is to employ Mespere LifeSciences NeurOs Cerebral Oximetry system, equipped with noninvasive sensors approved by the FDA, to monitor and investigate the correlation within a cohort of patients suffering from traumatic brain injury (TBI), stroke, brain tumor, and brain bleeding. This study aims to investigate and establish the correlation between blood vessel functionality parameters-specifically, Vasodilation/Constriction Index (VDC), Vascular Resistance Index (VR), and Volume Reactivity Index (VRx)-with the crucial physiological indicators, Intracranial Pressure (ICP) and Mean Arterial Pressure (MAP). By doing so, the investigators seek to address fundamental questions surrounding cerebral hemodynamics and autoregulation in various neurological conditions.

Eligibility

Min Age: 18 YearsMax Age: 100 Years

Plain Language Summary

Simplified for easier understanding

This observational study is comparing non-invasive measurements of blood vessel function with invasive measurements of brain pressure in patients already receiving intensive neurological care. The goal is to see if simpler non-invasive tests can predict what is happening in the brain. **You may be eligible if...** - You are an adult (over 18) - You are already in the hospital receiving neurological or neurocritical care - You have a diagnosis such as traumatic brain injury, brain hemorrhage, stroke, or brain tumor - You already have an arterial line for blood pressure monitoring as part of your care - You already have an intracranial pressure monitor in place as part of your care - You or your legal representative can provide consent **You may NOT be eligible if...** - You do not have continuous blood pressure and brain pressure monitoring already in place - You or your legal representative is unable or unwilling to consent to participation Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEIntracranial Pressure Noninvasive Monitoring

Mespere sensors will be placed on the temporal areas of the head in patients with invasive intracranial pressure monitoring. Blood pressures, intracranial pressure, and Mespere parameters will be recorded.