RecruitingNot ApplicableNCT06513195

EUS-guided Response Assessment to NSBB

Endoscopic Ultrasound Guided Response Assessment to Non-selective Beta-blockers in the Treatment of Clinically Significant Portal Hypertension

Sponsor

Universitaire Ziekenhuizen KU Leuven

Enrollment

24 participants

Start Date

Jul 17, 2024

Study Type

INTERVENTIONAL

Conditions

Portal Hypertension Related to Cirrhosis

Summary

The goal of this clinical trial is to learn if endoscopic ultrasound (EUS)-guided portal pressure measurement can determine the treatment response to non-selective beta-blockers (NSBB) in patients with cirrhosis and clinically significant portal hypertension (CSPH). Participants will undergo EUS-guided portal pressure measurement before start of Carvedilol en after three months of treatment. EUS-guided measurements will be paired with transjugular hepatic venous pressure gradient (HVPG) measurement as well as non-invasive tests for assessment of portal hypertension.

Eligibility

Min Age: 18 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study is examining whether an ultrasound-guided procedure (called EUS) can measure blood pressure in liver-related blood vessels as accurately as the standard invasive test, in order to predict how well patients with liver cirrhosis respond to blood pressure-lowering medications called beta-blockers. **You may be eligible if...** - You have a clinical or confirmed diagnosis of compensated liver cirrhosis (liver scarring without major complications yet) - You have signs suggesting high pressure in the liver's blood vessels (called CSPH) - You have not yet started beta-blocker treatment - You are between 18 and 80 years old - You are willing to undergo both types of pressure measurements **You may NOT be eligible if...** - You are pregnant or breastfeeding - You have liver cancer (HCC) along with cirrhosis - You have had a liver transplant or TIPS (a shunt procedure) - You have non-cirrhotic portal hypertension - You have a blood clot in the portal vein - Your bilirubin levels are significantly elevated (more than 3 mg/dL) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREendoscopic ultrasound-guided portal pressure measurement

The portal pressure gradient will be determined by endoscopic ultrasound-guided pressure measurement in the hepatic vein and the portal vein. The gradient will be calculated by substracting the hepatic vein pressure from the portal vein pressure.