Differential Effects of in Vivo and Virtual Exposure Therapy in Agoraphobia

This study is comparing real-world exposure therapy (facing feared situations in person) against virtual reality exposure therapy for people with agoraphobia (fear of open or crowded spaces), to see which approach works better and understand how the body responds during each. **You may be eligible if...** - You have a diagnosis of agoraphobia with or without panic disorder (experimental group) - OR you have social phobia (clinical control group) - OR you are a healthy person without any mental illness (control group) - A co-existing mild depression diagnosis is acceptable in the experimental and clinical control groups **You may NOT be eligible if...** - You have schizophrenia, bipolar disorder, substance dependence, dementia, eating disorders, PTSD, active major depressive episode, or personality disorder - You have significant physical health conditions such as cancer, cardiovascular disease, epilepsy, or autoimmune/metabolic conditions - You take psychiatric medications (antidepressants are an exception) or medications affecting the heart - You are currently in psychotherapy - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.