Vaccine Immunity and Inflammation in the Aging Person Living With HIV

This study is examining whether HIV-positive adults on antiretroviral therapy have a different immune response to pneumococcal vaccines compared to HIV-negative people, and whether HIV-related inflammation affects vaccine effectiveness. **You may be eligible if...** - You are 18 or older - You are HIV-positive and on antiretroviral therapy with a viral load below 200 in the past year - Controls: HIV-negative individuals aged 18 or older who are willing to have blood drawn **You may NOT be eligible if...** - You have another significant condition that suppresses the immune system - You are under 18 - You are pregnant at enrollment - You have a known contraindication to pneumococcal vaccination - You have severe anemia (hemoglobin below 8 g/dL) - You are currently incarcerated - You are unable to provide consent Talk to your doctor to see if this trial is right for you.