RecruitingNCT06514781

The Application of Different Sedation Protocols in ICU Patients With Severe Pneumonia

Sponsor

Xiangya Hospital of Central South University

Enrollment

600 participants

Start Date

Jan 1, 2024

Study Type

OBSERVATIONAL

Conditions

Severe Pneumonia

Summary

This study collected data from 600 patients with severe pneumonia to compare the duration of mechanical ventilation under different sedation regimens in real-world settings. It also evaluated and compared the sedation success rates, hemodynamic changes, and clinical outcomes of patients with severe pneumonia.

Eligibility

Min Age: 18 Years

Inclusion Criteria6

(1)From February 1, 2023, to March 30, 2024, diagnosed with severe pneumonia in the Respiratory Intensive Care Unit of Xiangya Hospital, Central South University. The diagnosis of severe pneumonia is based on meeting at least one major criterion or three or more minor criteria:
Major criteria:
①Infectious shock requiring vasopressor therapy despite adequate fluid resuscitation;②Respiratory failure requiring tracheal intubation or mechanical ventilation.
Minor criteria:
Respiratory rate ≥ 30 breaths/min; ②Oxygenation index (PaO2/FiO2) ≤ 250;
Involvement of multiple lobes; ④Altered mental status and/or disorientation; ⑤Blood urea nitrogen ≥ 20 mg/dl (7.14 mmol/L); ⑥Systolic blood pressure < 90 mmHg requiring aggressive fluid resuscitation. (2)Patients receiving mechanical ventilation who require sedation treatment. (3)Age ≥ 18 years.

Exclusion Criteria4

Allergic to routine sedative or analgesic medications.
Patients who have not undergone pain and sedation assessment.
Patients transferred to another hospital during treatment.
Patients who abandon treatment and are discharged within less than 72 hours of treatment.

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