RecruitingPhase 4NCT06515730

Treatment With Apixaban Versus Warfarin in Patients With Left Ventricular Thrombus After Acute Myocardial Infarction

RandomizEd compariSOn of Apixaban Versus Warfarin in Patients With Left VEntricular Thrombus After Acute Myocardial Infarction (RESOLVE-AMI)


Sponsor

Karolinska Institutet

Enrollment

212 participants

Start Date

Apr 8, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The optimal anticoagulant for the treatment of left ventricular (LV) thrombus following acute myocardial infarction (AMI) is unclear. The aim of this multicenter randomized study is to evaluate the efficacy of apixaban versus warfarin with respect to thrombus resolution in patients with LV thrombus after AMI.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Apixaban and a drug called Warfarin for people with acute myocardial infarction and left ventricular thrombus. The study is currently recruiting participants at 16 locations. People eligible for this study include aged 18 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGApixaban

5 mg tablet twice a daily with dose reduction according to label

DRUGWarfarin

2.5 mg tablet once daily, with individual dosing according to coagulation tests


Locations(16)

Falu lasarett

Falun, Sweden

Sahlgrenska University hospital, Mölndal

Gothenburg, Sweden

Sahlgrenska University hospital, Östra

Gothenburg, Sweden

Sahlgrenska University hospital

Gothenburg, Sweden

Linköping University hospital

Linköping, Sweden

Skånes Universitetssjukhus Lund

Lund, Sweden

Skånes University hospital, Malmö

Malmö, Sweden

Vrinnevi hospital

Nörrköping, Sweden

Örebro University hospital

Örebro, Sweden

Karolinska Insitutet

Stockholm, Sweden

Danderyds hospital

Stockholm, Sweden

Karolinska Univerity Hospital

Stockholm, Sweden

Sankt Görans Hospital

Stockholm, Sweden

Södersjukhuset

Stockholm, Sweden

Uppsala Akademiska hospital

Uppsala, Sweden

Västmanlands hospital, Västerås

Västerås, Sweden

View Full Details on ClinicalTrials.gov

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NCT06515730


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