Characterizing the Inflammation Around Dental Implants: Bacterial Infection, Hypersensitivity or Both?
McGill University Health Centre/Research Institute of the McGill University Health Centre
40 participants
Sep 22, 2022
OBSERVATIONAL
Conditions
Summary
The use of titanium dental implants has become a common modern treatment to restore teeth. Although the success rate of dental implants is high, inflammation around the dental implant still occurs. The current study will investigate if the inflammation around the implant is due to bacterial infection, hypersensitivity or both.
Eligibility
Inclusion Criteria2
- Received at least one functional implant (implant restored with a prothesis);
- Did not receive peri-implant mucositis and peri-implantitis treatment in the past three months.
Exclusion Criteria10
- Dental records with incomplete information;
- Individuals with a weak immune system or chronic disease such as diabetes, heart, lung or kidney disease;
- Pregnant women;
- Individuals undergoing orthodontic therapy and those who have oral piercing.
- History of diseases that modify or suppress the immune and inflammatory response, including rheumatoid arthritis, diabetes, lupus, and inflammatory bowel disease and metastatic cancer;
- Taking medications that cause antiresorptive osteonecrosis of the jaw (including any dose of intravenous bisphosphonates, oral bisphosphonate intake for more than three years, receptor activator of nuclear factor kappa-B ligand inhibitors, or antiangiogenic medications);
- Taking medications known to induce gingival hyperplasia including anticonvulsants, immunosuppressants, or calcium channel blockers;
- Taking steroid medications, systemic or local antibiotics in the last three months (as this may affect the interleukins activity);
- Received radiation therapy to the head and neck or chemotherapy;
- Received treatment to manage an inflamed implant, including management of peri-implantitis and peri-implant mucositis in the last three months.
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Interventions
Clinical examination of a dental implant
Collection of a sample of peri-implant crevicular fluid
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06515886