RecruitingNCT06515964

China Early Esophageal Cancer Cohort

Development and Validation of a Curability Evaluation Model for Endoscopic Resection of Early Esophageal Squamous Cell Carcinoma Based on China Early Esophageal Cancer Cohort


Sponsor

Changhai Hospital

Enrollment

1,000 participants

Start Date

Oct 1, 2022

Study Type

OBSERVATIONAL

Conditions

Summary

With the development of endoscopy, more and more patients with superficial esophageal squamous cell carcinoma (ESCC) receive endoscopic resection rather than traditional surgery. However, there is still no complete consensus on the risk factors for lymph node metastasis (LNM) and recurrence of ESCC after endoscopic resection. The existing curative resection criteria are strict to a certain extent, and a considerable number of patients are overtreated according to the current standard of additional treatment. Thus, we aim to conduct a multi-center retrospective and prospective study to construct a large cohort of ESCC based on the previously established multi-center collaborative research network and clinical big data, analyze the risk factors of LNM and recurrence in patients with early esophageal squamous cell carcinoma after ESD, establish an accurate and simple risk prediction model, and evaluate the discrimination efficiency of this model.


Eligibility

Min Age: 15 YearsMax Age: 85 Years

Plain Language Summary

Simplified for easier understanding

This study is building a long-term database of patients in China who were treated for early-stage esophageal (food pipe) cancer using a minimally invasive procedure called endoscopic submucosal dissection (ESD), where a thin camera is used to remove a surface tumor without open surgery. The goal is to understand long-term outcomes and identify patterns of recurrence. **You may be eligible if...** - You are 18–85 years old - You had ESD performed to treat an early-stage squamous cell cancer of the esophagus, and the procedure followed current guidelines - Your tumor was at an early stage (pT1a or pT1b) after the procedure - You have been followed up for at least 3 years after your ESD, or your cancer returned or spread to lymph nodes during follow-up **You may NOT be eligible if...** - You received chemotherapy or radiation to the esophagus, or had esophageal surgery, before the ESD procedure - You have a history of stomach or duodenal cancer, pre-cancerous growths, or adenomas Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERobservational study

observational study, no intervention


Locations(1)

Changhai Hospital

Shanghai, Shanghai Municipality, China

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NCT06515964


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